Abstract :Complementary and alternative medical treatments are proposed for autism spectrum disorders (ASDs) [1]. ASDs result from complex environment-gene interactions. An epigenetic mechanism that appears to play a role in ASDs involves low activity of methyl-CPG-binding protein-2 (MECP2) at CpG islands in genes within cells localized to the frontal cerebral cortex, resulting in hypermethylation of DNA. Hypomethylationdue to reduced availability of S-adenosyl methionine (SAM), an important donor of methyl groups, is shown to occur in mothers of children affected by ASDs [2]. Low activity of MECP2 is associated with disinhibition of his tone deacetylase-1 (HDAC1) which inhibits the chromatin condensation required for silencing of genes and limiting protein synthesis. It is hypothesized that down regulation of HDAC1 by valproic acid and of glycogen synthase kinase-3beta (GSK3ß) by lithium may upregulate one of the main eukaryotic cell differentiation signaling mechanisms, the wingless nt-1 proto-oncogene (Wnt) pathway [3].